视觉皮层和海马体的主观空间位置的连贯编码
Aman B Saleem1,2, E Mika Diamanti3,4, Julien Fournier3
1UCL Institute of Ophthalmology, University College London, London, UK. aman.saleem@ucl.ac.uk.
Nature
|September 12, 2018
概括
小鼠的视觉皮层 (V1) 神经元显示空间调制,表明导航信号影响早期的感觉处理. 这些信号与海马导航表示一致,并反映主观位置估计.
科学领域:
- 神经科学
- 计算神经科学
- 感官处理
背景情况:
- 视觉对于导航至关重要,
- 之前的研究表明空间位置信号在视觉皮层的早期出现.
研究的目的:
- 研究主要视觉皮层 (V1) 中的空间信号的性质.
- 确定这些信号是否通过导航信息和主观位置估计进行调节.
主要方法:
- 在虚拟现实走廊中记录了小鼠V1和海马CA1的神经活动.
- 在不同位置使用相同的视觉地标来区分视觉和空间反应.
- 训练小鼠将特定位置与水奖励联系起来以推断主观位置.
主要成果:
- 大多数V1神经元表现出空间调节,根据位置对相同的视觉地标作出不同的反应.
- 在V1和CA1中的神经群体编码了动物的位置和相关的表示错误.
- V1和CA1的表现更好地反映了动物的主观位置 (从行为推断出来),而不是其实际位置.
结论:
- 在V1的视觉反应受到导航信号的显著影响.
- 这些在V1中的导航信号与海马信号一致,并反映了动物的主观空间意识.
- 这些发现表明导航信息从早期皮质区域透到感官处理中.
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