在学习过程中编码历史的区域特异性和可塑性
Ryoma Hattori1, Bethanny Danskin1, Zeljana Babic1
1Neurobiology Section, Center for Neural Circuits and Behavior, Department of Neurosciences, and Halıcıoğlu Data Science Institute, University of California San Diego, La Jolla, CA 92093, USA.
Cell
|May 14, 2019
概括
大脑为决策编码主观价值. 后皮质 (RSC) 独特地保持价值和历史信号,对于适应性行为和学习奖励历史至关重要.
科学领域:
- 神经科学
- 认知神经科学
- 决策科学
背景情况:
- 决策依赖于通过经验形成的主观价值.
- 为了有效的决策, 大脑必须编码和保持主观价值.
研究的目的:
- 在皮层中研究价值编码的区域特异性和可塑性.
- 确定特定皮质区域在编码值和历史信号中的作用.
主要方法:
- 在基于价值的决策任务中训练小鼠.
- 在6个皮质区域的神经活动图像与细胞分辨率
- 使用急性逆皮层 (RSC) 失活.
主要成果:
- 历史和价值相关的信号广泛存在,但在皮层区域的强度和时间模式上有所不同.
- 在专家小鼠中,后皮层 (RSC) 独特地编码了与历史和价值相关的信号,并具有持久的活动模式.
- RSC的独特编码在学习过程中出现, 增加了远程奖励历史的信号.
- 选择性地损害了基于奖励历史的决策策略.
结论:
- 后皮质 (RSC) 在灵活更新历史编码方面发挥着至关重要的作用.
- RSC 持续编码与价值相关的信号以支持适应性决策.
- 神经皮层中的神经回路在价值和历史信号表示上表现出可塑性.
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