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Updated: Dec 23, 2025

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage
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Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage

Published on: August 21, 2021

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从单个细胞分裂错误产生癌症基因组复杂性的机制

Neil T Umbreit1,2,3, Cheng-Zhong Zhang4,5, Luke D Lynch2,3

  • 1Howard Hughes Medical Institute, Chevy Chase, MD, USA. neilt_umbreit@dfci.harvard.edu david_pellman@dfci.harvard.edu cheng-zhong_zhang@dfci.harvard.edu.

Science (New York, N.Y.)
|April 18, 2020
PubMed
概括

由细胞分裂错误引发的染色体断裂融合桥梁 (BFB) 循环驱动癌症中的基因放大和基因组不稳定. 这一过程涉及actomyosin力量和DNA复制突发, 推动染色体和癌症的演变.

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