相关实验视频
Updated: Jul 16, 2025

04:46
The Quantification of Injectability by Mechanical Testing
Published on: May 13, 2020
8.0K
辅料和包装材料对玻璃和聚合物预填注射器功能的影响
1West Pharmaceutical Services, Inc., 530 Herman O. West Drive, Exton, PA 19341.
PDA journal of pharmaceutical science and technology
|September 15, 2023
概括
循环烯聚合物 (COP) 预填注射器 (PFS) 在与各种药物辅助物相互作用时,提供比玻璃PFS更一致的挤出力. 这种更好的可预测性对于精确的药物输送应用至关重要.
科学领域:
- 材料科学 材料科学 材料科学
- 制药技术 制药技术 制药技术
- 药物运输 药物运输 药物运输
背景情况:
- 预填注射器 (PFS) 是药物产品的关键初级包装.
- 化玻璃PFS由于与药物配方的相互作用,可以表现出可变的挤出力.
- 稳定的挤出力对于准确的剂量是必不可少的,特别是在敏感的应用中.
研究的目的:
- 为了比较循环烯聚合物 (COP) PFS与传统玻璃PFS的挤出力性能.
- 评估各种辅助剂和加速储存条件对PFS挤出力的影响.
- 了解PFS性能差异的物质基础.
主要方法:
- 使用COP和化玻璃PFS对挤出力进行比较分析.
- 用各种辅助剂组合进行测试,包括缓冲剂,强化剂和表面活性剂.
- 暴露于加速储存条件以模拟长期稳定性.
- 在单个挤出冲动中评估力的一致性.
主要成果:
- 与玻璃PFS相比,COP PFS在测试条件下表现出更一致和可预测的挤出力.
- 在COP PFS中,在每次冲程中,挤出力变异明显较小.
- 观察到的差异归因于COP与化玻璃的固有稳定性和同质性以及它们与辅助剂的相互作用.
结论:
- 与玻璃PFS相比,COP PFS在挤出力的一致性方面提供了卓越的性能.
- COP的材料特性有助于与制药辅助剂的可预测相互作用.
- 对于在药物输送过程中需要高精度和可靠性的应用,COP PFS 是一个有前途的替代方案.
相关概念视频
Factors Influencing Drug Absorption: Pharmaceutical Parameters
154
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
154
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism
332
Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
332
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry
229
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
229
Biopharmaceutics and Pharmacokinetics: Overview
2.1K
Understanding drugs, drug products, and their performance in pharmaceutical science is pivotal. Drugs, whether simple molecules or complex compounds, are designed to interact with the body's biological systems to diagnose, treat, or prevent diseases. Drug products include various delivery systems such as tablets, capsules, injections, and inhalers. The performance of these drug products is gauged by their ability to deliver the active ingredient to the desired site of action at the...
2.1K
Factors Influencing Drug Absorption: Physicochemical Parameters
322
The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
322
Polymer Classification: Crystallinity
2.9K
Unlike ionic or small covalent molecules, polymers do not form crystalline solids due to the diffusion limitations of their long-chain structures. However, polymers contain microscopic crystalline domains separated by amorphous domains.
Crystalline domains are the regions where polymer chains are aligned in an orderly manner and held together in proximity by intermolecular forces. For example, chains in the crystalline domains of polyethylene and nylon are bound together by van der Waals...
Crystalline domains are the regions where polymer chains are aligned in an orderly manner and held together in proximity by intermolecular forces. For example, chains in the crystalline domains of polyethylene and nylon are bound together by van der Waals...
2.9K

