Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Protein Families02:47

Protein Families

15.3K
Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism.   Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members.   If these new proteins contain similar amino acids in key...
15.3K
Multi-species Conserved Sequences02:51

Multi-species Conserved Sequences

3.9K
Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale  studies have provided new insights into the evolutionary relationship between organisms.
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved...
3.9K
Peptide Identification Using Tandem Mass Spectrometry01:33

Peptide Identification Using Tandem Mass Spectrometry

6.4K
Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...
6.4K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

PTEN Loss Promotes PI3Kβ Phosphorylation and EPHA2/SRC/p-PI3KβY962 Complex Assembly to Drive Tumorigenesis.

Cancer discovery·2025
Same author

Effective in vivo RNA base editing via engineered cytidine deaminase APOBECs fused with PUF proteins.

Nature communications·2025
Same author

Pan-tissue transcriptome analysis reveals sex-dimorphic human aging.

eLife·2025
Same author

When biomedical discovery faces data barriers: building a governance-empowered framework for resilient collaboration.

Molecular systems biology·2025
Same author

Boosting RNA nanotherapeutics with V-ATPase activating non-inflammatory lipid nanoparticles to treat chronic lung injury.

Nature communications·2025
Same author

Analysis of RNA translation with a deep learning architecture provides new insight into translation control.

Nucleic acids research·2025

相关实验视频

Updated: Jun 29, 2025

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions
06:50

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions

Published on: January 26, 2024

1.8K

通过并行和异质计算快速搜索多重蛋白序列.

Jiefu Li1, Ziyuan Wang2, Xuwei Fan2

  • 1CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China.

Bioinformatics (Oxford, England)
|March 28, 2024
PubMed
概括
此摘要是机器生成的。

合唱团加速了蛋白质序列数据库搜索,为大型数据集提供100倍以上的速度,而不是BLASTP. 这种新的系统可以在桌面工作站上高效地查询数千个蛋白质序列.

更多相关视频

Single Cell Multiplex Reverse Transcription Polymerase Chain Reaction After Patch-clamp
10:44

Single Cell Multiplex Reverse Transcription Polymerase Chain Reaction After Patch-clamp

Published on: June 20, 2018

9.8K
Multi-target Parallel Processing Approach for Gene-to-structure Determination of the Influenza Polymerase PB2 Subunit
22:10

Multi-target Parallel Processing Approach for Gene-to-structure Determination of the Influenza Polymerase PB2 Subunit

Published on: June 28, 2013

13.3K

相关实验视频

Last Updated: Jun 29, 2025

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions
06:50

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions

Published on: January 26, 2024

1.8K
Single Cell Multiplex Reverse Transcription Polymerase Chain Reaction After Patch-clamp
10:44

Single Cell Multiplex Reverse Transcription Polymerase Chain Reaction After Patch-clamp

Published on: June 20, 2018

9.8K
Multi-target Parallel Processing Approach for Gene-to-structure Determination of the Influenza Polymerase PB2 Subunit
22:10

Multi-target Parallel Processing Approach for Gene-to-structure Determination of the Influenza Polymerase PB2 Subunit

Published on: June 28, 2013

13.3K

科学领域:

  • 生物信息学是一种生物信息学.
  • 计算生物学 计算生物学
  • 基因组学就是基因组学.

背景情况:

  • 蛋白序列数据库搜索和多个序列对齐在生物信息学中至关重要.
  • 快速增长的序列数据需要大数据库的高效和可扩展的查询算法.

研究的目的:

  • 为了介绍Chorus,一个新的蛋白质序列查询系统.
  • 为了使数千个蛋白质序列与桌面工作站上的大型数据库同时查询.
  • 在不影响灵敏度的情况下实现显著的加快速度.

主要方法:

  • 利用并行模型和异质计算架构.
  • 开发了一个名为Chorus的新型蛋白质序列查询系统.
  • 与BLASTP等既有方法进行基准测试.

主要成果:

  • 与BLASTP相比,合唱团实现了超过100倍的加速度.
  • 在分析1.5TB元基因组数据集的证明有用性,用于在30分钟内发现新型CRISPR-Cas蛋白质.
  • 保持与现有方法可比的灵敏度.

结论:

  • 合唱团为大规模的蛋白质序列数据库查询提供了高效和可扩展的解决方案.
  • 该系统能够从庞大的数据集中快速发现新型蛋白质,例如CRISPR-Cas系统.
  • 合唱团是开源的,可用于更广泛的研究应用.