离子结合的多酸盐具有不同程度的聚合,用于控制出血
Laiqiang Tong1, Dong Zhang1, Zhenhua Huang1
1Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, P. R. China.
ACS applied materials & interfaces
|August 13, 2024
概括
离子合聚酸盐 (CaPP) 粉末被合成,以研究聚酸盐链长度对血液静止的影响. CaPP-50表现出卓越的静血性能,加速血液凝结和凝块稳定,有效控制出血.
科学领域:
- 生物材料科学 生物材料科学
- 血液静止研究 血液静止研究
- 材料化学 材料化学
背景情况:
- 有效的静血材料对于控制出血和促进伤口愈合至关重要.
- 无机聚酸盐 (polyP) 调节血凝,但其链长效应需要进一步研究.
- 离子 (Ca2+) 对凝血级联酶活性至关重要.
研究的目的:
- 合成和描述不同聚合度 (n=20,50,1500) 的离子合聚酸盐 (CaPP) 粉末.
- 为了评估聚聚链长度对静血疗效的影响.
- 评估CaPP作为活性无机血静剂的潜力.
主要方法:
- 离子交换反应以合成n=20,50和1500的CaPP粉末.
- 增加聚合的CaPP相变 (晶体到无形) 的表征.
- 通过血液凝结指数 (BCI) 和凝结时间进行血液静止性能的体外评估.
- 在体内验证使用老鼠肝脏出血和大腿动脉穿刺模型.
主要成果:
- 成功合成了CaPP粉末,表现出相位过渡,聚合度越来越高.
- CaPP增强了PolyP的湿透性,并证明了链长度依赖的静血活性.
- CaPP-50表现出最强的血静,BCI最低 (12.1 ± 0.7%) 和凝血时间最短 (302.0 ± 10.5秒).
- CaPP-50加速了血细胞的粘附/激活,启动了内在的凝血级联,并形成了稳定的血块.
- 在体内研究证实了CaPP-50的疗效,可与商业静血粉相提并优于考林.
- CaPP-50显示出优异的生物相容性和储存稳定性.
结论:
- CaPP-50,是一种与离子相结合的中链聚酸盐,显著增强血静.
- CaPP-50的机制涉及促进血细胞活动和稳定血栓形成.
- CaPP-50显示出作为一种临床上可行的无机血静剂,用于快速控制出血的有希望的潜力.
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