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Multicolor Flow Cytometry Analyses of Cellular Immune Response in Rhesus Macaques
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rhesus macaque 寿命的大脑图表

S Alldritt1, J S B Ramirez2,3, R Vos de Wael2

  • 1Center for the Integrative Developmental Neuroscience, Child Mind Institute.

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|September 11, 2024
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概括
此摘要是机器生成的。

这项研究为 rhesus 创造了第一个规范性大脑生长图表,这对于理解神经发育和老化在这个灵长类动物模型中至关重要. 这些图表有助于跨物种研究,推进翻译神经科学.

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科学领域:

  • 神经科学是一个神经科学.
  • 发展生物学 发展生物学
  • 比较解剖学的比较解剖学

背景情况:

  • 人类大脑发育有参考标准,但非人类灵长类 (NHP) 模型缺乏类似的生长图表.
  • rhesus 是有价值的 NHP 模型,因为它们在大脑解剖学,行为和遗传学上与人类有相似之处.
  • 了解NHP大脑发育对于翻译神经科学至关重要.

研究的目的:

  • 为了建立在 rhesus 的寿命中对大脑结构的规范性生长图表.
  • 为了绘制大脑体积,皮质厚度和表面积的发育轨迹.
  • 通过提供比较资源,促进跨物种的翻译研究.

主要方法:

  • 从PRIME-DE和其他来源收集了1,024只 rhesus的1,522张MRI扫描.
  • 为全球和区域大脑结构变化绘制非线性发育轨迹.
  • 开发了规范性图表,用于大脑结构的百分比分数.

主要成果:

  • 在整个生命周期中为 rhesus macaque 大脑结构提供了规范性生长图表.
  • 确定了从产前阶段到衰老的关键发展里程碑.
  • 揭示了物种特异性和人类可比的大脑成熟模式.

结论:

  • 开发的图表是NHP研究的宝贵资源,特别是那些样本规模有限的研究.
  • 这些发现增强了对子神经发育和衰老的理解.
  • 一个交互式的开放资源支持跨物种的比较,以推进翻译神经科学.