进口珠宝中的有毒性
Marissa Hauptman1,2,3, Marc Nascarella4, Jocelyn Silvester1,2
1Departments of Pediatrics.
Pediatrics
|October 1, 2024
概括
一个孩子 一个孩子
科学领域:
- 儿科毒理学 儿科毒理学
- 环境健康 环境健康
- 材料科学 材料科学 材料科学
背景情况:
- 中毒对儿童健康构成重大风险.
- 摄入外来物体可能导致有毒暴露.
- 金属珠宝是潜在的暴露源.
研究的目的:
- 报告一名儿童因摄入含有的章而导致中毒的情况.
- 分析摄入物体的组成和生物可用性.
- 使用已建立的药理动力学模型建模预测的血水平.
主要方法:
- 用X射线光光谱和场辐射扫描电子显微镜进行元素分析.
- 模拟胃提取以估计口服生物可用性.
- 美国环境保护局综合暴露吸收生物动力学 (IEUBK) 模型用于血水平预测.
主要成果:
- 奖章的组成是15%的,53%的铜和其他元素.
- 估计摄入量为7786微克/天,生物利用率为50%.
- 根据IEUBK的模型预测,血液中的含量将从2.05μg/dL上升到173.9μg/dL.
- 这枚奖章含含量是儿童珠宝所允许的550倍.
结论:
- 摄入金属珠宝可能会导致儿童严重,危及生命的中毒.
- 新型的暴露来源,如进口珠宝,构成全球环境健康风险.
- 严格的监管和意识是防止儿童从消费品中接触到的关键.
相关概念视频
Types of Toxins
1.6K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
1.6K
The Periodic Table and Organismal Elements
176.9K
Overview
176.9K
Prevention of Further Absorption of Poison
793
In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
793
Toxic Reactions: Overview
955
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
955
Anticholinesterase Agents: Poisoning and Treatment
808
Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
808
Minerals
286
Minerals are essential nutrients that the human body needs in small amounts to work properly. They play a vital role in many bodily functions, such as building strong bones and transmitting nerve impulses. Some minerals are needed for hormone production or to maintain a normal heartbeat. Major minerals include calcium, phosphorus, potassium, sulfur, sodium, chlorine, and magnesium, while trace minerals include iron, manganese, copper, iodine, zinc, cobalt, fluoride, and selenium.
Major...
Major...
286


