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开发强大的益生菌联盟:一种方法学优化方法.

Hina Maniya¹, Ishita Modasiya¹, Mehul Chauhan¹

¹Postbiotic and Foodomics Lab, Department of Microbiology, School of Science, RK University, Rajkot, Gujarat, 360020, India.

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这项研究表明,微生物代谢物显著影响益生菌联盟的发展. 细菌菌和细菌细菌菌株通过代谢物生产促进生长,增强多菌株益生菌配方.

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Published on: December 15, 2017

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科学领域:

微生物学微生物学
生物技术是生物技术.
益生菌研究益生菌研究

背景情况:

有效的益生菌联盟取决于理解复杂的菌株相互作用.
微生物代谢物在益生菌相容性中的作用在传统评估中经常被忽视.

研究的目的:

评估微生物菌株及其二次代谢物对多菌株益生菌配方兼容性的影响.
为了确定由益生菌共同培养中的代谢物介导的协同作用.

主要方法:

使用点位方法评估对抗性活性,以确定不兼容的菌株.
通过分析无细胞超浮体对共同培养生长的影响来评估协同作用的属性.
使用16SRNA测序识别的细菌分离物.

主要成果:

菌株PIG1FD和PIG1IR表现出对抗作用,使它们不适合联盟.
来自PIG6IR (Bacillus subtilis) 和PIG5CI (Bacillus spizizenii) 的细胞超物显著促进了其他菌株的生长.
PIG5CI加速了日志阶段进入0-2小时,而PIG6IR则加速了5-6小时.

结论:

细菌味菌BAB 7915 (PIG5CI) 和细菌细菌BAB 7918 (PIG6IR) 是益生菌联盟的有希望的候选人,因为代谢物介导的增长促进.
这项研究提供了一个新的方法来评估益生菌的兼容性,考虑代谢物效应.
这些发现为开发先进的多菌株益生菌配方提供了洞察力.