利用基因组数据的序列性质,改进分析和识别
M Saqib Nawaz1, M Zohaib Nawaz2, Zhang Junyi1
1College of Computer Science and Software Engineering, Shenzhen University, China.
Computers in biology and medicine
|November 2, 2024
概括
基因组数据分析得到了GenoAnaCla的增强,这是一种使用顺序模式挖掘 (SPM) 来进行病毒分类的新方法. 这种方法提高了识别和分类病毒基因组序列的准确性.
科学领域:
- 生物信息学是一种生物信息学.
- 基因组学就是基因组学.
- 计算生物学 计算生物学
背景情况:
- 基因组数据的指数增长给序列分析和分类带来了挑战.
- 现有的基因组分类模型往往忽视了核酸和氨基酸的序列性质,这对于理解病毒结构和功能至关重要.
研究的目的:
- 介绍GenoAnaCla,一种使用顺序模式挖掘 (SPM) 分析和分类基因组序列的新方法.
- 提高病毒基因组序列分类和检测的准确性和有效性.
主要方法:
- 基诺安克拉预处理RNA病毒基因组序列 (核酸,编码区域,蛋白质格式).
- 提取频繁的序列模式和规则在多种形式和编码子捕获序列特征.
- 使用八种不同的分类器,并使用各种指标评估它们的性能.
主要成果:
- 拟议的GenoAnaCla方法与现有方法相比,显示出更高的性能.
- 与最先进的基因组序列分类和检测技术相比,平均准确度增加了3.18%.
结论:
- GenoAnaCla有效地结合了序列信息,用于增强基因组序列分析和分类.
- 该方法在管理和理解病毒基因组数据方面取得了重大进步,这对于疫情准备至关重要.
相关概念视频
Evolutionary Relationships through Genome Comparisons
5.7K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
5.7K
Genomics
36.0K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
36.0K
Next-generation Sequencing
87.6K
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
87.6K
Genome Annotation and Assembly
18.8K
The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
18.8K
RNA-seq
9.8K
RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases.
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
9.8K
Sanger Sequencing
753.0K
DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...
753.0K


