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TIGIT通过调节免疫突触强度来影响固体瘤微环境中的CAR NK细胞效应器功能.

Ishwar Navin1, Matthew Dysthe2, Prashant S Menon3

  • 1Baylor College of Medicine, Houston, TX, United States.

Cancer immunology research
|July 30, 2025
PubMed
概括

从仿真抗原受体 (CAR) -NK细胞中删除TIGIT受体可以提高它们对抗固体瘤的能力. 这种修改改善了CAR-NK细胞在免疫抑制瘤微环境中的持久性和有效性.

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