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使用基于纳米机器人的眼液保持角膜

Chao Wan1,2, Gege Tian3, Mingjie Wang1

  • 1School of Medicine and Health, Harbin Institute of Technology, Harbin 150001, China. zhiguangwu@hit.edu.cn.

Journal of materials chemistry. B
|November 7, 2025
PubMed
概括

眼滴中的新型纳米机器人可以增强眼部治疗的药物保留力. 这些装有AmB的纳米机器人,在真菌角膜炎模型中积极改善角膜愈合.

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Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...