累积平均BMI与认知衰退之间的关联:一项为期24年的队列研究
Qianhui Xu1, Meng Hsuan Sung2, Zhuo Chen3,4
1Graduate School of Art and Science, New York University, New York, NY, 10012, USA.
Journal of neurology
|February 27, 2026
概括
高累积平均体重指数 (caBMI) 与更快的认知衰退有关. 这种效应在八年后最强烈,强调长期的体重管理对大脑健康有好处.
科学领域:
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
- 老年学是指老年学的学科.
背景情况:
- 高体重指数 (BMI) 与认知功能受损有关.
- 关于累积平均BMI (caBMI) 对认知健康的长期影响的研究有限.
- 了解caBMI的影响对于认知健康策略至关重要.
研究的目的:
- 研究caBMI与认知衰退之间的关联.
- 确定caBMI最强烈地预测认知衰退的关键时间窗口.
- 为长期体重管理策略提供信息,以保持认知功能.
主要方法:
- 利用了来自健康和退休研究 (1996-2020) 的数据.
- 通过对记忆和执行功能的综合评分来评估全球认知.
- 计算caBMI作为随访期间的平均BMI,并使用线性混合模型进行分析.
主要成果:
- 在caBMI上增加100个单位与全球认知,执行功能和记忆力的加速认知衰退相关.
- 在八年后观察到caBMI和认知衰退之间最强的关联.
- 老年人 (≥65岁) 与年轻人相比,caBMI和认知衰退之间存在更大的关联.
结论:
- 累积平均BMI与随着时间的推移与认知能力下降有显著联系.
- 体重管理和一致的BMI监测对于保持认知健康至关重要.
- 这些发现强调了解决神经健康的长期体重趋势的重要性.
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