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[The aged and stress response].

K Higashi1

  • 1Department of Biochemistry, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan.

Journal of UOEH
|August 6, 1999
PubMed
Summary
This summary is machine-generated.

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Aging reduces the body's ability to adapt to environmental changes by decreasing heat shock proteins (HSPs) and heat shock factor (HSF) activation, impacting cellular stress responses and increasing health risks.

Area of Science:

  • Molecular biology
  • Cellular aging
  • Stress response

Context:

  • Aging is associated with decreased adaptability to environmental stressors.
  • Cellular mechanisms underlying reduced adaptation potential in aged individuals require further elucidation.

Purpose:

  • To review experimental evidence supporting the hypothesis that aging impairs adaptation potential.
  • To explore the role of heat shock proteins (HSPs) and heat shock factor (HSF) in the aging process.

Summary:

  • Studies in humans, rats, and fibroblasts show reduced HSPs, mRNA, and HSF DNA binding activity with aging.
  • HSF activation from monomer to trimer is impaired in aged cells, potentially due to altered redox state or abnormal proteins.
  • HSP functions as a chaperone but can also contribute to toxic protein aggregation (e.g., amyloid fibers) and increased carcinogenic risk in aged cells.

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Impact:

  • Findings suggest that reduced HSP/HSF function contributes to impaired cellular adaptation during aging.
  • Understanding these molecular changes can inform strategies to mitigate age-related decline and disease risk.
  • The dual role of HSPs in cellular protection and potential toxicity highlights the complexity of aging processes.