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KID, a Kinase Inhibitor Database project.

O Collin1, L Meijer

  • 1Station Biologique de Roscoff, CNRS UPR 9042, Roscoff, Bretagne, France.

Pharmacology & Therapeutics
|August 24, 1999
PubMed
Summary
This summary is machine-generated.

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The Kinase Inhibitor Database offers structural and bibliographic data on protein kinase inhibitors. This specialized resource is curated by researchers for researchers in the field.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pharmacology

Background:

  • Protein kinases play crucial roles in cellular signaling pathways.
  • Dysregulation of protein kinases is implicated in various diseases, including cancer.
  • Targeting protein kinases with small molecule inhibitors is a key therapeutic strategy.

Purpose of the Study:

  • To establish a specialized database for protein kinase inhibitors.
  • To provide researchers with access to structural and bibliographic information on these inhibitors.
  • To facilitate data sharing and curation within the kinase inhibitor research community.

Main Methods:

  • Development of a World Wide Web accessible database.
  • Data collection through submissions from researchers in the kinase inhibitor field.

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  • Data curation and validation by a dedicated database curator.

    • Main Results:

    • A centralized repository of information on protein kinase inhibitors is now available.
    • Structural and bibliographic data are accessible to the scientific community.
    • A system for researcher-driven data submission and expert curation is established.

    Conclusions:

    • The Kinase Inhibitor Database serves as a valuable resource for researchers studying protein kinase inhibitors.
    • This initiative promotes collaborative data gathering and ensures data quality.
    • The database supports the advancement of kinase inhibitor drug discovery and development.