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Updated: Aug 9, 2026

Preparation and Maintenance of Dorsal Root Ganglia Neurons in Compartmented Cultures
Published on: October 17, 2008
[Interneuronal signaling mediated by the trans-synaptic diffusion of neurotransmitters]
M V Kopanitsia1, Ia A Boĭchuk, N O Lozova
1A. A. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kiev.
Abstract:
A great number of modern neurophysiological studies give evidence about the possibility of the extrasynaptic diffusion of the released neurotransmitters. Such observations challenge the established view on synapses as isolated communication channels between pre- and postsynaptic neurones. In the present review article, we consider the latest experimental data on the interneuronal cross-talk mediated by extrasynaptic diffusion of L-glutamate (L-Glu) and gamma-amino-butyric acid (GABA). Possible physiological significance of this phenomenon is also discussed.
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