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Accelerated nodulosis during methotrexate therapy for refractory rheumatoid arthritis. A case report
G Filosa1, F Salaffi, L Bugatti
1Division of Dermatology, A. Murri Hospital Jesi (An), Italy. gfilos@tin.it
Advances in Experimental Medicine and Biology
|December 22, 1999
Abstract:
Accelerated nodulosis (AN) is a potential complication of methotrexate (MTX) therapy for rheumatoid arthritis (RA). We report on a 62-year old man affected by seropositive RA who developed AN after five months of MTX treatment. MTX-dose reduction was followed by rapid regression of the skin nodules. The Authors describe the typical features of AN and discuss on the pathogenetic mechanisms.