Related Experiment Video
Updated: Aug 11, 2026

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
[The nonoliguric form of kidney failure in the posthemorrhagic period]
1O. O. Bogomoletz National Medical University, Kiev.
Abstract:
At research of rules of deviations of the parameters homeostasis for patients with bleedings we pursued to find dependence of the parameters of homeostasis from function of kidneys. The researches were carried out in the early posthemorrhagic period on an example of inspection of the patients who were operated concerning gastrointestinal and intraabdominal hemorrhages. Is revealed, that the renal insufficiency, which arose at 23.21% surveyed, proceeded without oliguria--in the neoliguric form. It was characterized by normal speed diuresis, despite of the essential damages of the function of nephron: infringement of a primary filtration in glomerulus, reabsorption of water and electrolytes in tubules, restriction of excretion H+. Normal diuresis in such cases was explained by the early and duly beginning of the infusion therapy, owing to what, probably, the infringement of passableness tubules was prevented. Despite of it, the patients with the damaged function of kidneys require the careful control of spent therapy because of an opportunity of dangerous deviations of the parameters homeostasis of norm. Confirmation it became the reduction, fixed at such patients, clearance of electrolytes, infringement of the extraction of acid by kidneys.
Related Concept Videos
Dialysis
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Acute Kidney Injury I: Introduction
Acute Kidney Injury II: Pathophysiology
Acute Kidney Injury III: Clinical Manifestations
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Acute Kidney Injury V: Interprofessional Care

