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Photo-regulated duplex- and triplex-formation of the modified DNA carrying azobenzene
H Asanuma1, X Liang, T Yoshida
1Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Japan.
Nucleic Acids Symposium Series
|April 26, 2000
Abstract:
The duplex- and triplex- forming activity of oligonucleotide was photo-regulated by using the isomerization of azobenzene in the side chain. When the azobenzene was isomerized from the trans-form to the cis-form by photo-irradiation, the melting temperatures of the duplex and triplex between the oligonucleotide and its complementary counterpart were significantly lowered.