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The metabolic hypothesis revisited
1Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia 19104-6085, USA.
Advances in Experimental Medicine and Biology
|June 13, 2000
Abstract:
High levels of CO are used to mimic the stimulatory response of the CSN initiated by hypoxia. Using light of different wavelengths we show that the stimulatory effects of high CO can be pinpointed to the cytochrome c oxidase in the mitochondrial respiratory chain. This supports the metabolic theory of oxygen sensing in the mitochondria.