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Elevated basal activity of tryptophan oxygenase in alcohol-preferring C57BL mice
E D Vasil'eva1, T V Yakovleva, S I Il'nitskaya
1Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk.
Bulletin of Experimental Biology and Medicine
|September 8, 2000
Abstract:
Tryptophan oxygenase activity in alcohol-preferring C57Bl mice and control CBA and DBA/2 mice was studied under nonstressful conditions and after glucocorticoid-induced stress. Elevated basal tryptophan oxygenase activity in C57Bl mice is probably responsible for reduced brain content of tryptophan and serotonin associated with alcohol preference.
