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[The immune response of viral hepatitis patients who use narcotic preparations]

I S Starostina1, V V Bogach, O E Trotsenko

  • 1Research Institute of Epidemiology and Microbiology, Territorial Mental Health Center, Khabarovsk, Russia.

Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
|September 20, 2000
PubMed

The characteristics of cell-mediated and humoral immunity were studied in 611 patients with different etiological forms of acute virus hepatitides (HB, HC, HB + C, HC + HBsAg). As the result of the systematic abuse of psychoactive preparations, introduced by intravenous injection, in 166 patients (27.2%) drug addiction developed, ehile 445 (72.8%) patients had no addiction. The study revealed that in drug users with HB the secondary T-cell immunodeficiency of the hyposuppressor type in combination with depression in B-cell-mediated immunity (a decrease in the absolute number of B lymphocytes) could be registered, and in patients having no drug addiction the secondary T-cell immunodeficiency characterized by a decrease in the content of T helpers simultaneously with the increased content of T suppressors and B lymphocytes.

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