[Endothelial factors in the regulation of Na+, K(+)-ATPase]

Endothelial vasoactive agents such as endothelin, angiotensin, nitric oxide and others are essential in regulation of the Na-pump functions in vascular and others tissues. In our review the intracellular mechanisms of activating and inhibition of the Na+,K(+)-ATPase by endothelial vasoactive agents are discussed. In the control of vascular tone and heart function as well as the regulation of the Na-pump endothelial vasoactive agents act individually or in close interaction with other physiologically active substances including the ouabain-like factor, endogenous inhibitor of the Na-pump. Some aspects ouabain-like factor physiological action are under the discussion. Recent advances in study and comprehension of intracellular mechanisms the mediating role of endothelial agents in Na-pump regulation are reviewed also.