[Allergies to ketoprofen gels]

Area of Science:

• Dermatology
• Photodermatology
• Pharmacology

Background:

• Ketoprofen gels are frequently used for benign conditions.
• Local intolerance, including eczema and photoallergy, is a common adverse effect.
• Reactions can be severe, spreading beyond application sites and causing generalized responses.

Purpose of the Study:

• To investigate the mechanisms behind ketoprofen-induced contact photosensitization.
• To identify potential cross-reactivity with other substances.

Main Methods:

• Photoallergological testing was employed for diagnosis.
• Analysis of the chemical structure of ketoprofen was performed.

Main Results:

• Photoallergological tests confirmed ketoprofen-induced contact photosensitization.
• The benzophenone ring in ketoprofen was identified as a key factor.
• Cross-allergies with fenofibrate and oxybenzone were observed.

Conclusions:

• Ketoprofen's benzophenone structure contributes to photosensitivity reactions.
• Patient and prescriber education on sun avoidance is essential.
• Awareness of potential cross-reactivity is important for managing adverse reactions.