Related Experiment Videos
T1 hypointensities and axonal loss
F Barkhof1, G B Karas, M A van Walderveen
1Department of Radiology, Multiple Sclerosis MRI Research Centre Amsterdam, Vrije Universiteit Hospital, 1007 MB Amsterdam, The Netherlands. F.Barkhof@AZVU.NL
Neuroimaging Clinics of North America
|May 22, 2001
Abstract:
T1 hypointensities are lesions that are hypointense on moderately T1-weighted conventional spin-echo sequences and serve as markers of matrix destruction and axonal loss. They correlate better with clinical disability than T2-weighted images, are found in patients with progressive multiple sclerosis, and can be used as surrogate outcome measures in treatment trials.