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Facilitated tissue expansion with topical estriol.
M Tercan1, Y Cokkeser, I Ozyazgan
1Department of Plastic and Reconstructive Surgery, Gaziantep University, Turkey.
Annals of Plastic Surgery
|June 19, 2001
Summary
Topical estriol significantly enhances tissue expansion in rats, proving more effective than hyaluronidase. While estriol improved expansion rates, it reduced tissue breaking strength compared to controls.
Area of Science:
- Plastic Surgery
- Dermatology
- Endocrinology
Background:
- Tissue expansion is a vital reconstructive plastic surgery technique.
- Current methods require optimization for improved outcomes.
Purpose of the Study:
- To investigate the efficacy of topical estriol in enhancing tissue expansion.
- To compare the effects of estriol and hyaluronidase on tissue expansion rates and tissue integrity.
Main Methods:
- Twenty-four male Wistar rats were divided into three groups: topical base cream (control), hyaluronidase, and estriol.
- Agents were applied topically for five weeks to assess effects on tissue expansion.
- Breaking strength of expanded tissue was measured in estriol and control groups.
Main Results:
- Both hyaluronidase (p < 0.05) and estriol (p < 0.001) significantly enhanced the rate of tissue expansion compared to the control group.
- Estriol demonstrated superior enhancement of expansion compared to hyaluronidase (p < 0.05).
- Tissue breaking strength was significantly higher in the control group than in the estriol group (p < 0.05). Necrotic changes precluded breaking strength evaluation in the hyaluronidase group.
Conclusions:
- Topical estriol effectively enhances the rate of tissue expansion.
- Estriol may serve as an adjunctive agent to facilitate tissue expansion in reconstructive surgery.
- Further research is needed to address the impact of estriol on tissue strength.