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Torsades de pointes caused by Mibefradil
S Gläser1, M Steinbach, C Opitz
1Unfallkrankenhaus Berlin, Department of Internal Medicine, Warener Strasse 7, D-12683 Berlin, Germany.
Abstract:
We report a case of symptomatic Torsades de pointes due to QTc prolongation by Mibefradil, which potentially explains unexpected deaths related to this drug. Multiple episodes of Torsades de pointes were documented in a 76-year-old woman with significant QTc prolongation of 0.53 s. After discontinuation of Mibefradil QTc intervals normalized and no further ventricular tachyarrythmias were observed. We conclude that Mibefradil can cause QTc prolongation and life threatening ventricular dysrhythmias.
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