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Epstein-Barr virus dacryoadenitis resulting in keratoconjunctivitis sicca in a child
J Merayo-Lloves1, S Baltatzis, C S Foster
1Ocular Immunology and Uveitis Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA.
American Journal of Ophthalmology
|December 4, 2001
Summary
Severe dry eye syndrome in a child was successfully treated with acyclovir and cyclosporin A. This case highlights Epstein-Barr virus as a cause of pediatric keratoconjunctivitis sicca.
Area of Science:
- Ophthalmology
- Pediatrics
- Virology
Background:
- Severe dry eye syndrome (keratoconjunctivitis sicca) can significantly impact a child's quality of life.
- Primary Sjögren syndrome is a common autoimmune cause of dry eye, but other etiologies should be considered in pediatric cases.
Observation:
- A 10-year-old male presented with severe dry eyes, pain, and photophobia unresponsive to conventional treatments.
- Lacrimal gland histology suggested primary Sjögren syndrome.
- Serologic and immunohistologic findings indicated Epstein-Barr virus (EBV) as the causative agent.
Findings:
- Systemic treatment with acyclovir and cyclosporin A led to a rapid and dramatic improvement in the patient's dry eye symptoms.
- The patient was able to resume normal daily activities following treatment.
Implications:
- Epstein-Barr virus dacryoadenitis should be included in the differential diagnosis for pediatric keratoconjunctivitis sicca.
- Acyclovir therapy, combined with anti-inflammatory suppression, offers a successful treatment strategy for EBV-induced dry eye in children.