Related Experiment Videos
Outcome after surgical treatment
Katherine D Holland1, Elaine Wyllie
1Section of Pediatric Epilepsy, Department of Neurology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA. hollank1@ccf.org
Neurosurgery Clinics of North America
|January 5, 2002
Summary
Epilepsy surgery for cortical development malformations can lead to seizure freedom in 50% of patients. Complete resection, confirmed by imaging and EEG, is key to successful outcomes in children and adults.
Area of Science:
- Neurosurgery
- Epileptology
- Developmental Neuroscience
Background:
- Intractable epilepsy in children and adults can stem from malformations of cortical development.
- Surgical intervention is a critical treatment option for these patients.
Purpose of the Study:
- To evaluate the efficacy of surgical resection for epilepsy caused by cortical development malformations.
- To identify factors influencing seizure control post-surgery.
Main Methods:
- Surgical procedures included lobar, multilobar resections, and hemispherectomy.
- Post-operative outcomes were assessed based on seizure frequency.
- Completeness of resection was evaluated using Magnetic Resonance (MR) imaging and electroencephalography (EEG).
Main Results:
- Approximately 50% of patients achieved complete seizure freedom after surgery.
- An additional 20% experienced only rare seizures post-operatively.
- Surgical success correlated with the completeness of the cortical malformation resection.
Conclusions:
- Surgery offers significant potential for seizure control in patients with epilepsy due to cortical development malformations.
- Complete resection, verified by MR imaging and EEG, is crucial for maximizing positive outcomes.
- Surgical options are tailored to individual patient needs, including infants, children, and adults.