Persisting epithelial herpes simplex keratitis while on cyclosporin-A ointment.

Area of Science:

• Ophthalmology
• Immunology

Background:

• Reports the first known adverse effect of cyclosporin-A (CsA) ointment on epithelial herpes simplex virus (HSV) keratitis in a corneal graft recipient.
• Highlights a potential complication in post-keratoplasty care.

Observation:

• A patient receiving CsA ointment developed epithelial HSV keratitis.
• The condition persisted despite standard topical treatments.

Findings:

• Discontinuation of CsA ointment led to the successful resolution of epithelial HSV keratitis.
• This suggests CsA-induced immunosuppression contributed to the persistent viral infection.

Implications:

• Clinicians should consider the potential for CsA to exacerbate HSV keratitis in corneal grafts.
• Careful monitoring and potential adjustment of immunosuppressive therapy may be necessary for patients with a history of HSV.