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[Study on the coagulation state of sudden deafness]
1Department of Laboratory Medicine, First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000.
Lin Chuang Er Bi Yan Hou Ke Za Zhi = Journal of Clinical Otorhinolaryngology
|February 5, 2003
Summary
Sudden deafness (SD) involves enhanced coagulation and platelet activity with decreased anticoagulation before treatment. Secondary fibrinolytic activity increases post-treatment, suggesting thrombosis is a key factor in SD.
Area of Science:
- Hematology
- Otolaryngology
- Vascular Biology
Context:
- Sudden deafness (SD) is an idiopathic condition impacting auditory function.
- Understanding the underlying pathophysiology of SD is crucial for effective treatment strategies.
Purpose:
- To investigate the roles of coagulation, anticoagulation, and fibrinolytic activity in patients with sudden deafness.
- To assess the impact of treatment on these hemostatic parameters.
Summary:
- Coagulation and platelet functions were elevated, while anticoagulation and fibrinolytic activity were reduced in SD patients before treatment.
- Following a month of treatment (vitamins, dextranum, etc.), coagulation and platelet functions normalized compared to controls.
- Elevated D-dimer levels were observed post-treatment, indicating increased fibrinolysis.
Impact:
- Findings suggest that enhanced coagulation and platelet activity, alongside impaired fibrinolysis, contribute to the pathogenesis of sudden deafness.
- The study highlights the potential role of thrombosis in SD and the effectiveness of treatments in restoring hemostatic balance.