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[The expression of transforming growth factor alpha and its receptor in nasal polyps]
1Department of Otolaryngology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032.
Objective:
To assess the possible role of expression of TGF alpha and EGFR in nasal polyps and its relationship with PCNA labeling index.
Method:
Specimens from 20 patients of nasal polyps were studied with immunohistochemical technique.
Result:
The expression of TGF alpha, EGFR and PCNA were increased in the epithelium, gland cells and inflammatory cells of nasal polyps. There was a close correlation between the intensities of TGF alpha, EGFR and PCNA.
Conclusion:
TGF alpha may play a key role in epithelial cell proliferation in nasal polyps.
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