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[Effects of modified SD therapy on Bell's palsy]
1Department of Otorhinolaryngology, 304th Hospital of People's Liberation Army, Beijing 100037.
Lin Chuang Er Bi Yan Hou Ke Za Zhi = Journal of Clinical Otorhinolaryngology
|February 5, 2003
Summary
A modified Salvia miltiorrhiza (SD) therapy, combining hydrocortisone and dextran, significantly improved recovery rates for Bell
Area of Science:
- Neurology
- Pharmacology
- Internal Medicine
Background:
- Bell's palsy (BP) is a common neurological disorder causing facial paralysis.
- Conventional treatments for BP can lead to severe side effects.
- The need for effective and safer treatment options for BP is critical.
Purpose of the Study:
- To evaluate the efficacy of a modified Salvia miltiorrhiza (SD) therapy in treating Bell's palsy.
- To assess the safety profile of the modified SD therapy, specifically regarding hepatic and renal side effects.
- To compare the modified SD therapy with standard prednisone treatment.
Main Methods:
- A modified SD therapy (intravenous high-dose hydrocortisone and low molecular dextran) was administered to 71 BP patients.
- A control group of 32 BP patients received prednisone.
- Curative rates and detailed side effects were recorded and compared between the groups.
Main Results:
- The modified SD therapy group showed a significantly higher curative rate (95.8%) compared to the prednisone group (81.2%).
- Early administration within 24 hours yielded the highest recovery rate (75.0%) in the modified SD group.
- The modified SD therapy group experienced no significant hepatic, renal, or gastric side effects.
Conclusions:
- The modified SD therapy offers a potentially superior and safer treatment for Bell's palsy.
- Early intervention with modified SD therapy is crucial for maximizing recovery rates.
- This approach may reduce the risk of severe adverse events associated with BP treatment.