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Updated: Jul 16, 2026
09:18
Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
Published on: December 27, 2016
Neuronal survival and cell death signaling pathways
Richard S Morrison1, Yoshito Kinoshita, Mark D Johnson
1Department of Neurological Surgery, University of Washington School of Medicine, Box 356470, Seattle, Washington 98195-6470, USA.
Advances in Experimental Medicine and Biology
|February 11, 2003
Summary
Neuronal viability relies on complex signaling pathways. Stress and pathology disrupt these pathways, potentially activating active cell death mechanisms in neurons.
Area of Science:
- Neuroscience
- Cell Biology
- Pathology
Background:
- Neuronal viability depends on intricate signaling networks.
- Cellular stresses and neurological diseases can disrupt these pathways.
- Evidence suggests degenerating neurons may undergo active cell death.
Purpose of the Study:
- To review current evidence on cell death regulatory pathways in nervous system injury and degeneration.
- To examine the activation of anti- and pro-cell death pathways.
Main Methods:
- Literature review of recent evidence.
- Analysis of signaling pathways involved in neuronal stress response.
- Examination of pathways affecting mitochondrial and nuclear integrity.
Main Results:
- Signaling pathway imbalance is critical in neuronal fate after stress.
- Active cell death mechanisms involve specific signaling pathways.
- These pathways impact mitochondrial function, energy metabolism, and nuclear integrity.
Conclusions:
- Understanding these pathways is crucial for addressing nervous system injury and degeneration.
- Regulatory pathways play a key role in neuronal survival or death.
- Further research into these pathways could inform therapeutic strategies.
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