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[Reactive changes in circulating neutrophilic granulocytes in physiologic and complicated gestational process]
1A.A. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kiev.
Fiziolohichnyi Zhurnal (Kiev, Ukraine : 1994)
|April 3, 2003
Summary
Neutrophils in women with pregnancy-induced hypertension show nuclear and ultrastructural changes. Their degranulation suggests involvement in humoral regulation during EPH gestosis.
Area of Science:
- Cell Biology
- Immunology
- Obstetrics
Context:
- Pregnancy-induced hypertension (EPH gestosis) affects maternal health.
- Neutrophils play a role in immune responses and inflammation.
- Understanding neutrophil function is crucial in gestational pathologies.
Purpose:
- To comparatively analyze the morpho-functional characteristics of circulating neutrophils.
- To investigate neutrophil behavior in women with physiological pregnancy versus EPH gestosis.
- To correlate neutrophil changes with the clinical severity of EPH gestosis.
Summary:
- Electron microscopy revealed nuclear alterations (heterochromatin/euchromatin ratio, nucleolemma changes) in neutrophils from women with EPH gestosis.
- Cytoplasmic glycogen and granules significantly decreased, with exocytosis-mediated extraleukocytic release of granule contents observed.
- Neutrophils demonstrated functional activity within the vascular bed, indicating a potential role in humoral regulation.
Impact:
- Provides insights into neutrophilpathology during pregnancy-induced hypertension.
- Suggests neutrophils are active participants in the pathophysiology of EPH gestosis.
- Highlights potential mechanisms of neutrophil involvement in pregnancy-related vascular complications.