[Monitoring of renal function in burn patients with radioimmunological evaluation]

Urinary beta 2-microglobulin, albumin, IgG, Tamm-Horsfall mucoprotein, and glycoprotein were determined on PBD 0, 1, 3, 7, 14, 21, 27. It was found that the amount of albumin was double that of normal in patients with burn extent of 30%-50% TBSA, while IgG showed no change. In patients with over 50% TBSA burns, Alb was five-fold and IgG four-fold of normal. They probably indicated the degree of damage to the glomeruli. In 27 patients with infection, beta 2-m was increased, indicating damage to the proximal convoluted tubules. Glycoprotein showed a tendency to increase in moderate and severe burns, while it was markedly reduced in very large burns or renal failure, indicating damage to the ascending limb of thick medullary loop. The changes in the amount of urinary protein were more sensitive in reflecting early functional changes of the kidney.