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Updated: Aug 13, 2026

Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma
Published on: June 10, 2017
The histologic diagnosis of Hodgkin's disease
1Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston 77030.
Abstract:
Histologic criteria for the diagnosis of Hodgkin's disease are being modified, primarily as a result of phenotypic analysis. It seems likely that non-Hodgkin's lymphomas have been diagnosed as mixed-cellularity and lymphocytic-depletion Hodgkin's disease on the basis of previously accepted histologic criteria. As a result, phenotypic studies are indicated in all examples of lymphocytic-depletion Hodgkin's disease and in those cases of mixed-cellularity Hodgkin's disease in which the histologic findings are unusual. The effects of genotypic analysis on histologic criteria remain to be elucidated.
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