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[Anaplastic large cell lymphoma and keratoacanthoma]
1Hautklinik, Städtisches Krankenhaus Hildesheim. m.tronnier@stk-hildesheim.de
Summary
CD30-positive lymphoproliferative disorders like anaplastic large cell lymphoma can present with pseudoepitheliomatous hyperplasia. This case highlights a rare association where a keratoacanthoma developed within an anaplastic large cell lymphoma plaque.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- CD30-positive lymphoproliferative disorders, including anaplastic large cell lymphoma (ALCL) and lymphomatoid papulosis (LyP), can exhibit pseudoepitheliomatous hyperplasia.
- While epithelial tumors are infrequently linked to ALCL or LyP, CD30-positive cells are often found within the infiltrate of tumors like basal cell carcinomas and keratoacanthomas.
Observation:
- A 66-year-old male patient presented with a rapidly growing epithelial tumor within a plaque of ALCL.
- Clinical and histological examination classified this tumor as a keratoacanthoma.
Findings:
- The case demonstrates a rare instance of a keratoacanthoma developing within an existing ALCL lesion.
- Histological analysis revealed an intimate interaction between CD30-positive lymphocytes and epithelial cells at the tumor site.
Implications:
- This case underscores the complex interplay between immune cells (CD30-positive lymphocytes) and epithelial cells in the context of lymphoproliferative disorders.
- Understanding this interaction may offer insights into tumor development and progression in related conditions.