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[Ca2+] and [Na+] in rat ventricular myocytes showing negative and positive force frequency relationships
J E Frampton1, S M Harrison, C H Orchard
1Department of Physiology, University of Leeds, U.K.
Advances in Experimental Medicine and Biology
|January 1, 1992
Abstract:
Ventricular cells that show a positive force-frequency relationship show graded changes of intracellular [Ca2+] (Cai), [Na+] (Nai) and sarcoplasmic reticulum Ca2+ content with changes of stimulation frequency. Cells that show a negative force-frequency relationship show smaller changes of Nai and no change in the Ca2+ load of the sarcoplasmic reticulum as stimulation frequency is changed.