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Fighting tuberculosis: an old disease with new challenges.
Rama P Tripathi1, Neetu Tewari, Namrata Dwivedi
1Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow, 226001, India. rpt_56@yahoo.com
Medicinal Research Reviews
|September 25, 2004
Summary
Tuberculosis (TB) is a major global killer, worsened by HIV and drug resistance. This review covers TB control, drug targets, existing treatments, and future strategies for new anti-TB agents.
Area of Science:
- Microbiology
- Infectious Diseases
- Drug Discovery
Background:
- Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a significant global health threat.
- The co-occurrence of TB and HIV exacerbates mortality and disease spread.
- Drug-resistant strains of Mycobacterium tuberculosis limit the effectiveness of current anti-TB therapies.
Purpose of the Study:
- To provide a comprehensive overview of tuberculosis control efforts.
- To discuss current and novel drug targets for anti-TB agent development.
- To review existing anti-TB agents and explore future prospects for new drug discovery.
Main Methods:
- Literature review of existing studies on tuberculosis.
- Analysis of socioeconomic factors impacting TB in developing countries.
- Identification and categorization of known and newly discovered drug targets.
Main Results:
- Socioeconomic challenges in developing nations significantly affect TB control.
- Various drug targets in Mycobacterium tuberculosis, including cell wall and nucleic acid biosynthesis pathways, are being explored.
- Existing anti-TB agents, natural products, and lead molecules are discussed in the context of resistance.
Conclusions:
- Developing new anti-TB agents is crucial due to widespread drug resistance.
- A multi-faceted approach combining socioeconomic interventions and novel drug development is necessary.
- Continued research into drug targets and natural products offers promising avenues for future TB treatment.