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Updated: Aug 21, 2026

Preparation of Contiguous Bisaziridines for Regioselective Ring-Opening Reactions
Published on: July 28, 2022
Group-selective ring-closing enyne metathesis: concentration-dependent selectivity profile of
Sarah V Maifeld1, Reagan L Miller, Daesung Lee
1Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, USA.
Abstract:
Highly group-selective ring-closing metathesis of alkynylsilyloxy-tethered dienynes was achieved by using Grubbs first- and second-generation catalyst. The remarkable selectivity increase at higher concentration for differentiating between two alkene moieties in nearly identical steric and stereoelectronic environments is believed to be the result of a higher ring-closure rate for smaller-sized ring formation under rapid pre-equilibration of the two alkylidene species generated from either alkene moiety.
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