Immunoprotective effects of prolactin during stress-induced immune dysfunction
E E Fomicheva1, E A Nemirovich-Danchenko, E A Korneva
1Department of General Pathology and Pathophysiology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg, Russia. fomivhev@AG8070.spb.edu
Bulletin of Experimental Biology and Medicine
|September 30, 2004
Abstract:
We showed for the first time that prolactin stimulates the synthesis and release of immunomodulating cytokines and lymphocyte-activating factors (e.g., interleukin-1) by peritoneal macrophages. Prolactin abolished the stress-induced inhibition of proliferation of peripheral blood lymphocytes and increased cell sensitivity to regulatory effects of interleukin-1 in the reaction of lymphocyte blast transformation. These data illustrate the mechanism of immunoprotective activity of prolactin during stress.

