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Updated: Aug 7, 2026
09:58
Investigating the Three-dimensional Flow Separation Induced by a Model Vocal Fold Polyp
Published on: February 3, 2014
[The study of correlation between HPV and vocal cord polyp]
Bing Lian1, Jiqun Wang, Lihua Wang
1Department of Otorhinolaryngology , First Affiliated Hospital of JNMC,Guangzhou 510630.
Lin Chuang Er Bi Yan Hou Ke Za Zhi = Journal of Clinical Otorhinolaryngology
|October 30, 2004
Summary
Human papillomavirus (HPV) is strongly correlated with vocal cord polyps (VCP). HPV DNA was detected in 68% of VCP cases, suggesting a significant role in their development.
Area of Science:
- Otolaryngology
- Virology
- Pathology
Context:
- Vocal cord polyps (VCP) are benign growths affecting the larynx.
- The role of human papillomavirus (HPV) in VCP etiology is not fully understood.
Purpose:
- To investigate the correlation between HPV infection and the occurrence of VCP.
- To analyze the histopathological and ultrastructural features of VCP in relation to HPV presence.
Summary:
- Histopathological examination of 99 VCP specimens revealed koilocytoid cells in 55.6%.
- HPV-DNA was detected in 68% of 50 VCP cases using PCR.
- A significant correlation was found between koilocyte-like cells and HPV detection (92.9% HPV-positive in koilocytotic cases vs. 36.4% in non-koilocytotic cases).
- Electron microscopy findings supported light microscopy, with discrepancies noted in koilocyte-like cell identification.
Impact:
- Establishes a significant association between HPV and VCP.
- Suggests HPV as a potential causative agent in VCP development.
- Provides a basis for further research into HPV-targeted therapies for VCP.
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