[The relationship between tumor angiogenesis and cellular proliferation activity in nasal inverted papilloma]

To investigate the expression of CD34 and proliferating cell nuclear antigen (PCNA) and to study the relationship between tumor angiogenesis and cellular proliferation activity in nasal inverted papilloma (NIP).

The expression of CD34 protein and proliferating cell nuclear antigen were detected in 30 cases of NIP, 16 cases of nasal polyps (NP) and 11 cases of nasal squamous cell carcinoma (NSCC) with immunohistochemical S-P method and the tumor angiogenesis (as assessed by MVD) and cellular proliferation activity (as assessed by PCNA labeling index, PCNA-LI) was evaluated.

A significant difference in CD34 expression was found among the three diseases above mentioned. The MVD were 32.41 +/- 5.68; 53.22 +/- 9.31 and 80.37 +/- 10.21 in NP, NIP and NSCC. The expression rate of PCNA (PCNA-LI) was 28.67 +/- 9.29; 35.35 +/- 7.02 and 63.18 +/- 12.17 in NP, NIP and NSCC (P<0.01). There was a significant difference in PCNA expression among the three diseases (P<0.01). A significant positive correlation was found between MVD and PCNA-LI (r=0.56, P<0.01). Tumors with a low PCNA-LI was associated with low MVD and vice versa.

With a significant relation between tumor angiogenesis, cellular proliferation activity and pathological types, MVD, PCNA-LI can be used as a strong independent indicator to judge tumor aggressive behavior, proliferative activity, development of local or regional metastases and prognosis in nasal inverted papilloma.