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Confocal microscopy of posterior polymorphous endothelial dystrophy.
Lulu L Cheng1, Alvin L Young, Angus K K Wong
1Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong.
Cornea
|June 22, 2005
Summary
In vivo confocal microscopy reveals characteristic endothelial changes in posterior polymorphous endothelial dystrophy (PPED). This technique can help identify subclinical cases of PPED by detecting corneal abnormalities.
Area of Science:
- Ophthalmology
- Corneal Science
- Microscopy
Background:
- Posterior polymorphous endothelial dystrophy (PPED) is a rare, inherited corneal disorder.
- Understanding its in vivo presentation is crucial for diagnosis and management.
Purpose of the Study:
- To document the in vivo confocal microscopic features of PPED.
- To assess the utility of confocal microscopy in diagnosing PPED.
Main Methods:
- Observational case series involving six subjects from two families with PPED.
- In vivo confocal light microscopy examination of the corneal endothelium.
Main Results:
- Confocal microscopy showed endothelial craters, streaks, and cracks in PPED patients.
- Pleomorphism, polymegathism, guttae, and abnormal endothelial cell clusters were observed.
- These findings were absent in unaffected individuals.
Conclusions:
- In vivo confocal microscopy is valuable for detecting subclinical PPED.
- The study identified specific abnormalities of the Descemet membrane and corneal endothelium.