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Updated: Aug 16, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Pyrimidines as the cytostatic drugs
1Department of Organic Chemistry, School of Medicine, 9 Grodzka Str., 50-137 Wrocław, Poland.
Abstract:
Investigations on new cytostatic drugs have attracted a worldwide interest during the past few years. The pyrimidine derivatives possessing such the activity are amongst the biologically active compounds of a considerable pharmaceutical significance. All the research works on syntheses of these compounds are aimed at modifications in the cytosine ring or at changes in the dihydrofolic acid structure as well as at condensation of the pyrimidine ring system with other aromatic or heterocyclic rings.
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