[Effect of alimentary cholesterol loading on dynamics of serum testosterone and estradiol in rats ]

Some background mechanisms of the sex hormones changes in blood serum of the male rats under the alimentary loading by cholesterol during 21 weeks were investigated. Results suggested that in the conditions of the cholesterol loading estradiol level in the experimental rats was higher than similar indexes in animals of a control group. In relation to the testosterone level the later was lower during 12 weeks while since 15 week it exceeded the control levels. The possible mechanisms of redistribution in the biosynthesis of steroid hormones in the conditions of loading by cholesterol are discussed.