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Updated: Aug 14, 2026

Demonstrating a Multi-drug Resistant Mycobacterium tuberculosis Amplification Microarray
Published on: April 25, 2014
High frequency of multidrug-resistant Mycobacterium tuberculosis isolates in Georgetown, Guyana
Nikolai Menner1, Ingo Günther, Helmut Orawa
1Department of Medical Microbiology and Immunology of Infection, Charité- University Medicine Berlin, and Institute for Microbiology, Immunology, and Laboratory Medicine, Hospital Zehlendorf-Heckeshorn, Berlin, Germany.
Abstract:
Emergence of multidrug-resistant (MDR) Mycobacterium tuberculosis isolates constitutes a threat to public health worldwide. This study aimed at acquiring first epidemiological data for Guyana. Thirty-six M. tuberculosis isolates from patients of the Georgetown Chest Clinic were subjected to susceptibility testing on solid agar and in broth media. Resistance to at least one first-line drug was observed in 8 (22.2%, 95% confidence interval 8.3-36.1%) and simultaneous resistance to rifampicin and isoniazid (MDR) in 4 (11.1%, 95% confidence interval 0.6-21.6%) of the 36 isolates. The risk of infection with resistant isolates was significantly related to earlier antituberculosis therapy (P=0.040). These data indicate a high proportion of resistant M. tuberculosis isolates in Guyana and call for the implementation of control strategies based on an improved laboratory diagnosis of TB.
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