Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gelastic epilepsy. A clinical contribution.

P Iannetti1, L Chessa, U Raucci

  • 1Department of Pediatrics, University La Sapienza Rome, Italy.

Clinical Pediatrics
|August 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparing the responses of countries and National Health Systems to the COVID-19 pandemic: a critical analysis with a case-report series.

European review for medical and pharmacological sciences·2023
Same author

Gene Expression Changes in a Prefinal Health Stage of Lethally Irradiated Male and Female Rhesus Macaques.

Radiation research·2022
Same author

Direct-acting antivirals used in HCV-related liver disease do not affect thyroid function and autoimmunity.

Journal of endocrinological investigation·2022
Same author

Predicting the Radiation Sensitivity of Male and Female Rhesus Macaques Using Gene Expression.

Radiation research·2020
Same author

Putting Photomechanical Switches to Work: An <i>Ab Initio</i> Multiple Spawning Study of Donor-Acceptor Stenhouse Adducts.

The journal of physical chemistry letters·2020
Same author

Primary headache in childhood associated with psychiatric disturbances: an update.

European review for medical and pharmacological sciences·2020
Same journal

Effect of Preferred Language on Pediatric Rapid Response Activation and Subsequent Intensive Care Utilization.

Clinical pediatrics·2026
Same journal

Documented Caregiver Report of Wheezing at Home is Associated With Decreased Length of Pediatric Asthma Hospitalizations.

Clinical pediatrics·2026
Same journal

The Rash That Will Not Go Away.

Clinical pediatrics·2026
Same journal

Virtual Reality Education for Hospitalized Pediatric Patients Improves Intrinsic Motivation: A Prospective, Randomized Crossover Study.

Clinical pediatrics·2026
Same journal

Pediatric Invasive Group A Streptococcus Characteristics Before, During, and After COVID-19.

Clinical pediatrics·2026
Same journal

Lichen Sclerosus: A Common but Often Overlooked Condition in Pediatric Patients.

Clinical pediatrics·2026
See all related articles

Gelastic epilepsy, characterized by laughing spells, is often linked to brain abnormalities. This study explores rare cases, including structural brain defects and potential genetic causes, revealing insights into its neurophysiology.

Area of Science:

  • Neurology
  • Neuroscience
  • Epileptology

Background:

  • Gelastic epilepsy is a rare seizure disorder characterized by episodes of laughter.
  • It is typically associated with specific brain lesions, including hypothalamic hamartomas and pituitary tumors.

Observation:

  • This study reports on four cases of gelastic epilepsy.
  • Three cases involved identifiable neurodevelopmental abnormalities: hamartoma of the tuber cinereum, lobar holoprosencephaly, and lissencephaly type I, grade 2.
  • One case presented with normal imaging, suggesting a possible genetic etiology due to familial idiopathic epilepsy.

Findings:

  • Electroencephalograms (EEGs) in all patients demonstrated both focal spikes and generalized spike-and-wave discharges.
  • The findings suggest that diffuse cortical hyperexcitability and subsequent thalamocortical network dysfunction may underlie the neurophysiologic disorder in gelastic epilepsy.

Related Experiment Videos

Implications:

  • Understanding the diverse etiologies of gelastic epilepsy is crucial for accurate diagnosis and management.
  • Further research into the neurophysiologic mechanisms, including genetic factors, is warranted.
  • These findings contribute to the broader understanding of epilepsy and its complex underlying brain circuitry.