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Role of calcium in toxic and programmed cell death
S Orrenius1, D J McConkey, P Nicotera
1Department of Toxicology, Karolinska Institutet, Stockholm, Sweden.
Advances in Experimental Medicine and Biology
|January 1, 1991
Abstract:
An uncontrolled and sustained increase in cytosolic Ca2+ concentration has been implicated as an early event in the development of anoxic or toxic cell injury. More recently it has become clear that an elevation of cytosolic Ca2+ is also involved in programmed cell death in the immune system. Here, we review some of our recent studies and provide further evidence for the role of Ca2+ in cell killing.